Differences between Tolerance and Tachyphylaxis of Drugs Pharmacology Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a Intermediate Cu(II) Thiolate Species in the Reduction of Cu(II)GHK by Glutathione: A Handy Chelate for Biological Cu(II) Reduction Inorganic Chemistry Not too big. Not too small. Because of their intermediate size, macrocyclic peptides combine the potency and precise targeting of an antibody or biologic therapy with the stability and ease of administration of a Tachyphylaxis an overview ScienceDirect Topics